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Grey's Anatomy
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What it is
The doctors of Grey Sloan Memorial Hospital deal with life-or-death consequences on a daily basis -- it's in one another that they find comfort, friendship and, at times, more than friendship. Together they're discovering that neither medicine nor relationships can be defined in black and white. Real life only comes in shades of grey.
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s23e01 · 2026-10-16
Episode guide
17 this season · 467 totals04e01 A Change Is Gonna Come 2007-09-28 01:00
A Change Is Gonna Come
Having just returned from her honeymoon with Meredith, Cristina searches for Burke, but he's nowhere to be found. Meredith, Cristina, Izzie and Alex spend their first day as residents with their own groups of interns - among the interns are George, repeating his intern year after failing his exams, and Lexie Grey, Meredith's half-sister whom she has never met. Now that Derek's relationship with Meredith has reached an emotional impasse, he looks to his fellow doctors for friendship; Bailey wrestles with her place within the hospital now that her former interns report to new Chief Resident Callie; and Richard resumes his position as Chief of Surgery.
s04e02 Love/Addiction 2007-10-05 01:00
Love/Addiction
The residents and interns treat the victims of a massive explosion at an apartment building, while Alex investigates the cause of the accident, Mama Burke returns to collect her son's things just as Cristina trades her wedding presents in exchange for surgeries, Lexie tries to have a heart-to-heart with an unwilling Meredith, and while Callie is overwhelmed with her duties as Chief Resident, Bailey searches for an outlet for her pent-up leadership skills.
s04e03 Let the Truth Sting 2007-10-12 01:00
Let the Truth Sting
The new interns are dazzled by the skill level of fellow intern George, while Lexie helps keep his 'repeater' status a secret; Meredith half-heartedly helps Lexie with her first emergency patient; Sloan and Richard attempt a radical, new surgery to save a woman's ability to speak; and George is compelled to tell Callie of his past indiscretion with Izzie.
s04e04 The Heart of the Matter 2007-10-19 01:00
The Heart of the Matter
The Chief's wife, Adele, rushes their niece to Seattle Grace, the hospital where she once had her prom, Izzie reveals her feelings for George to a mutual friend, and the reaction is not what she expects, Derek teaches Cristina how to be a better teaching resident, and the world's oldest living intern, Norman, misdiagnoses one of Meredith's patients.
s04e05 Haunt You Every Day 2007-10-26 01:00
Haunt You Every Day
It's Halloween, and the day is full of surprises for the doctors of Seattle Grace - Alex receives an unexpected and welcome visit from his former patient, Ava/Rebecca, Meredith is convinced that her mother's ashes are haunting her, Cristina is snubbed by a surgeon she admires, and Callie announces George and Izzie's affair to their fellow doctors.
s04e06 Kung Fu Fighting 2007-11-02 01:00
Kung Fu Fighting
With his marriage in turmoil, the Chief turns to his fellow male surgeons for a 'gentleman's evening,' Cristina and Izzie heatedly compete for the same surgeries and the favor of the doctor performing them, Meredith treats the survivor of a skydiving accident, and the doctors treat two injured finalists who are competing in a promotional competition.
s04e07 Physical Attraction... Chemical Reaction 2007-11-09 02:00
Physical Attraction... Chemical Reaction
George and Izzie's romantic chemistry is put to the test, Mark develops a crush on a fellow surgeon, and Callie's role as Chief Resident is in jeopardy.
s04e08 Forever Young 2007-11-16 02:00
Forever Young
The ER is filled with teenagers after a schoolbus crash, Bailey treats a patient who was her high school crush, Derek goes out on a date with a fellow doctor, and Thatcher enters the ER looking for Meredith.
s04e09 Crash Into Me, Part 1 2007-11-23 02:00
Crash Into Me, Part 1
An ambulance crash endangers the lives of the paramedics involved, as Meredith and the Chief work on-site to save them, Bailey treats a patient who refuses her help, and Ava returns for Alex and meets his other girlfriend in the process.
s04e10 Crash Into Me, Part 2 2007-12-07 02:00
Crash Into Me, Part 2
In the stunning conclusion of a two-part episode, Meredith furiously works to save the life of a paramedic trapped inside an ambulance, as her sister, Lexie, holds the life of a patient in her hands; Derek must rely on the help of a nurse to save a patient's life, as Bailey struggles to balance her personal life with her work.
s04e11 Lay Your Hands on Me 2008-01-11 02:00
Lay Your Hands on Me
Bailey's family faces a medical trauma, just as her marriage is falling apart; a surprise visit from George's mother comes as a shock to both Izzie and Callie; a faith healer challenges Erica and Alex's beliefs in traditional medicine; and Derek must deal with the aftermath of his kiss with Rose.
s04e12 Where the Wild Things Are 2008-04-25 01:00
Where the Wild Things Are
Meredith and her fellow residents compete in a surgical contest. Meanwhile George and Lexie adjust to their new apartment.
s04e13 Piece of My Heart 2008-05-02 01:00
Piece of My Heart
Addison returns to Seattle Grace to perform an operation and is taken aback by all of the changes in her old co-workers' lives.
s04e14 The Becoming 2008-05-09 01:00
The Becoming
The nurses' objections to McSteamy's trysts lead to the instating of a new 'date and tell' policy. Meanwhile news of Burke's latest career achievements force Cristina to face her feelings for her ex, Meredith and Derek admit a veteran soldier into their clinical trial, and Callie turns to Sloan in her time of need.
s04e15 Losing My Mind 2008-05-16 01:00
Losing My Mind
Dr. Wyatt refuses to let Meredith give up on therapy, Alex learns the truth about Rebecca's medical condition, the Chief insists that Erica perform a risky surgery on his mentor, and after receiving news of Burke, Cristina continues to do things contrary to her nature, going so far as cleaning her always-messy apartment.
s04e16 Freedom (1) 2008-05-23 01:00
Freedom (1)
On the two-hour season finale of 'Grey's Anatomy,' Meredith and Derek have one last shot at a successful outcome in their clinical trial, as the other surgeons work together to free a boy from a hardening block of cement. Meanwhile, Izzie helps Alex care for an ailing Rebecca, and Lexie discovers critical information about George's intern status.
s04e17 Freedom (2) 2008-05-23 01:00
Freedom (2)
Meredith and Derek have one last shot at a successful outcome in their clinical trial, as the other surgeons work to free a boy from a block of cement.